San Francisco Bay Area, CA

Mixed Signals in the San Francisco Bay Area Real Estate Market

The San Francisco Bay Area's real estate landscape reveals contrasting trends across office and industrial sectors.

Published 2026-11-06

The San Francisco Bay Area real estate market is currently exhibiting mixed signals, with notable disparities between the office and industrial sectors. According to The Registry, the office market is experiencing a decline in the availability of large contiguous spaces, while the industrial sector is witnessing significant leasing activity, indicating a complex economic environment affecting different segments of the market.

In the office sector, the supply of contiguous 100,000-square-foot office blocks has decreased to 35, down from a peak of 58 three years ago. This decline is occurring despite ongoing demand from 26 tenants actively seeking such large spaces, suggesting a tightening market that could exert upward pressure on office rents as availability diminishes 1.

Conversely, the industrial sector is showing resilience. Source Foundry, a semiconductor-equipment startup, recently signed the Peninsula's largest industrial lease of the third quarter, securing 116,000 square feet in South San Francisco. This transaction underscores the ongoing demand in the industrial sector, even amid broader market challenges, including a steep occupancy loss in the area 2.

Additionally, Eli Lilly has expanded its footprint by 82,232 square feet in South San Francisco, marking the largest R&D lease in the Peninsula for the third quarter. This expansion occurs against a backdrop of rising vacancy rates and landlords reducing asking rents, indicating that while overall market conditions may be softening, specific sectors like biotech continue to pursue growth opportunities 3.

As the San Francisco Bay Area navigates these mixed signals, stakeholders in the real estate market will need to closely monitor these trends to understand the evolving landscape and make informed decisions.

Sources

  1. The Registry (Bay Area) — San Francisco Down to 35 Office Blocks of 100,000 SQFT as Tech Chases Record Year of Large Deals
  2. The Registry (Bay Area) — Source Foundry, $5B Chip-Equipment Startup Taking On ASML, Leases 116,000 SQFT Warehouse in South San Francisco
  3. The Registry (Bay Area) — Eli Lilly Expands by 82,000 SQFT at Alexandria’s 279 E Grand Avenue in South San Francisco, Peninsula’s Largest Q3 R&D Lease
This article was generated with the assistance of AI from the cited third-party sources and IntellCRE's market data. Figures are as reported by the linked publishers.

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